AK-<wbr/>7

AK-7

CAT N°: 14004
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From 109.00 92.65

The sirtuin SIRT2 is a deacetylase which targets ?-tubulin, histone 4, forkhead transcription factors, and several other substrates.{21799} It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases.{21799,21800,21803} AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 ?M).{21802} In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment.{21802} In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.{21802}

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