MK-0457

MK-0457

CAT N°: 13600
Price:

From 129.00 109.65

The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis.{18438} MK-0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM).{17545} It shows selectivity against a panel of more than 190 different protein kinases.{17545} MK-0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s = 2/M phase.{18438}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-cyclopropanecarboxamide
  • Correlated keywords
    • mitosis aurora kinase inhibitor inhibit MK0457 MK-0457 MK-457 MK457 cell cycle cancer apoptosis tumor A B C MK 0457 VX-680 VX680 piperazine family serine-threonine serine threonine regulate stage mitotic function division amplification overexpression over-expression tumorigenesis pan-Aurora panAurora protein proliferation line clear renal carcinoma block growth tumor rodent model histone H3 H-3 phosphorylation apoptosis disrupt bipolar bi-polar spindle formation mitosis arresting arrest progression G2/M G2 M phase
  • Product Overview:
    The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis.{18438} MK-0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM).{17545} It shows selectivity against a panel of more than 190 different protein kinases.{17545} MK-0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s = 2/M phase.{18438}

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