Bisindolyl<wbr/>maleimide VIII (acetate)

Bisindolylmaleimide VIII (acetate)

CAT N°: 13333
Price:

From 75.00 63.75

Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.{17342,17339} This compound exhibits some degree of PKC isozyme specificity with preference for PKC? over PKC?I, PKC?II, PKC?, or PKC? (IC50s = 53, 195, 163, 213, and 175 nM, respectively).{17342} At 10 µM BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C ?1.{17340} BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 value of 600 nM.{17341}

We also advise you