PF-<wbr/>3845

PF-3845

CAT N°: 13279
Price:

From 43.00 36.55

Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 ?M).{17090} It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.{17090} PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.{17090}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
  • Correlated keywords
    • fatty acids hydrolase FAAH N-acyl ethanolamines NAEs endocannabinoids N-arachidonoyl ethanolamine anandamide AEA inhibitors inhibits inflammation pain PF3845 PF 3845 cannabinoids cbs synthetic Antibodies Monoclonal Monoclonal Antibodies
  • Product Overview:
    Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 ?M).{17090} It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.{17090} PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.{17090}

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