2-Acetyl-5-tetra<wbr/>hydroxybutyl Imidazole

2-Acetyl-5-tetrahydroxybutyl Imidazole

CAT N°: 13222
Price:

From 95.00 80.75

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo.{13428} THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation.{45874} In mice, THI (50 µg/ml in drinking water) increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs.{13428,17443} The resulting lymphopenia is reversible following cessation of THI treatment.{17442}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
  • Correlated keywords
    • tetrahydroxybutylimidazole tetrahydroxy-butylimidazole A-6770 2ATHBI
  • Product Overview:
    2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo.{13428} THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation.{45874} In mice, THI (50 µg/ml in drinking water) increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs.{13428,17443} The resulting lymphopenia is reversible following cessation of THI treatment.{17442}

We also advise you