M 344

M 344

CAT N°: 13174
Price:

From 97.00 82.45

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM){17304} as well as human HDAC1 (IC50 = 46 nM).{17305} It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively).{17306} M 344 enhances the sensitivity of human squamous carcinoma cells to radiation{17307} and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 ?M).{17308}

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