25-<wbr/>hydroxy Vitamin D<sub>2</sub>

25-hydroxy Vitamin D2

CAT N°: 12078
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25-hydroxy Vitamin D2 is a metabolite of vitamin D2 (Item No. 11791).{57807} It is formed from vitamin D2 by the cytochrome P450 (CYP) isoforms CYP2R1 and CYP27A1, which have 25-hydroxylase activity, and is bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream.{60080} 25-hydroxy Vitamin D2 is transported to the kidney, where it is preferentially 24-hydroxylated by CYP24A1 to produce 24,25-dihydroxy vitamin D2.{60080} It can also be hydroxylated by CYP27B1 to produce 1,25-dihydroxy vitamin D2.{60080,57807} Serum levels of 25-hydroxy vitamin D2 have been used as a marker of vitamin D status.{57808}

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