24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 ?M).{22051} It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 ?M. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).{22053}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 298690-60-5 |
| Molecular formula | C17H18FNO2S |
| Smiles | FC(C=C1)=CC=C1[C@@H]2CCCN2S(C3=CC=C(C)C=C3)(=O)=O |
| Molecular weight | 319,4 |
| Custom code | 2930.90 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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