B-<wbr/>HT 933 (hydro<wbr>chloride)

B-HT 933 (hydrochloride)

CAT N°: 11941
Price:

From 48.00 40.80

B-HT 933 is an agonist of ?2-adrenergic receptors (?2-ARs) with an EC50 value of 0.65 ?M for contraction of canine sapheneous veins.{35207} It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum.{35209} B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the ?2-AR antagonist yohimbine (Item No. 19869).{35211} B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 ?g/kg intracisternally.{32515} It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.{35216}

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