Indiplon

Indiplon

CAT N°: 11638
Price:

From 108.00 91.80

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.{25527,25525} Indiplon is selective for ?1 subunits (EC50 = 2.6 nM) as compared with ?2, ?3, or ?5 (EC50 = 24, 60, and 77 nM).{25527,25525} Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.{25528,25526}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-acetamide
  • Correlated keywords
    • ions channels neurosciences receptors biochemistry signals transductions positives allosteric modulators GABAs GABAa aminobutyric acids pyrazolopyrimidine ?-aminobutyric g-aminobutyric gamma-aminobutyric .gamma.-aminobutyric ? g gamma .gamma. sedatives hypnotic effects sleep onset maintenance durations NBIs NBI-34060 34060 NBI34060 inhibitory inhibits inhibitors inhibitions neurotransmitters mammals pyrazolopyrimidines high affinity high-affinity GABA-activated activated chloride currents dose-dependent doses dependents reversible selective alpha .alpha. ?1 subunits alpha1 .alpha.1 ?2 ?3 ?5 alpha2 .alpha.2 alpha3 .alpha.3 alpha5 .alpha.5
  • Product Overview:
    Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.{25527,25525} Indiplon is selective for ?1 subunits (EC50 = 2.6 nM) as compared with ?2, ?3, or ?5 (EC50 = 24, 60, and 77 nM).{25527,25525} Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.{25528,25526}

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