YM-155

YM-155

CAT N°: 11490
Price:

From 54.00 45.90

Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.{22213} It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.{22212} At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.{22212} YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.{22212,22211}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide
  • Correlated keywords
    • transcriptions factors cancers apoptosis sepantronium survivin IAP inhibitors inhibits inhibitions drugs 753440-91-4 resistances anti-tumors antitumors anti tumors YM155 YMs 155 transactivation promoters suppresses suppression p53 prostate pancreatic lung
  • Product Overview:
    Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.{22213} It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.{22212} At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.{22212} YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.{22212,22211}

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