Cyclopamine

Cyclopamine

CAT N°: 11321
Price:

34.00 28.90

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened.{20490,20488} By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia.{20490} As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM.{20490} Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.{20491,20489,18038}

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