Suramin (sodium salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt
• Correlated keywords
  • 145-63-1 90586-65-5 African sleeping sickness anti-trypanosomal antitrypanosomal anti trypanosomals trypans derivatives Bayer 205 bayer-205 antiproliferatives anti-proliferatives proliferatives Germanin inhibitors inhibits inhibitions calmodulin antagonists P2 purinergic receptors glycosaminoglycan anticancers antivirals cancers anti-cancers viral anti-virals polysulfonated naphthylurea binding binds binders ryanodine receptor-1 blocks blocking blockers G proteins G-proteins coupling GPCRs non-specific non specific competitors TGF? PDGF FGF insulin-like insulin growth factors factor-1 EGF PKC activity PKC TNF IL-2 IL IL2 transferrin Apo-B apoB Apo B blindness blind sick sleeps onchocerciasis cells lines lungs breast horomes refractory prostates metastatic renalcolorectal high-grades high grades gliomas agents mechanisms actions BAY-205 BAYs 205 BAY205 CL 1003 CI1003 CI-1003 fourneau 309 fourneau-309 germanin hexasodium carbamides moranyl NF060 NF-060 NFs 060 naganin naganines naphurides sodiums 90586-65-5 interleukins tumors necrosis TGF.beta. TGFB TGFb treatments river clinical evaluations regress Leishmania
• Product Overview:
  Suramin is a polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities.{62519} It is negatively charged at physiological pH and therefore binds to various intracellular targets including, but not limited to, ryanodine receptor 1 (IC50 = 4.9 µM), G protein-coupled receptors, P2 purinergic receptors, PDGF, PKC, transferrin, DNA and RNA polymerases, sirtuins, and various cytokines.{62519,23034,23035} It reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 µg/ml).{62520} In vivo, suramin induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis.{62521} Suramin (60 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of malignant mesothelioma.{62522} Formulations containing suramin have been used in the treatment of African sleeping sickness.