Bisindolyl<wbr/>maleimide III

Bisindolylmaleimide III

CAT N°: 11072
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From 91.00 77.35

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine.{17276,17275} At 1 ?M, bisindolylmaleimide III inhibits 93% of PKC? kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency.{12847} Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 ?M.

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