Thapsigargin

Thapsigargin

CAT N°: 10522
Price:

From 112.00 95.20

In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM).{19971,19972} Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells.{19971,19965,19970} In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects.{19977,19975}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydro-1H-cyclopenta[e]azulen-7-yl octanoate
  • Correlated keywords
    • calcium, ATPases, sarco/endoplasmic calcium ATPases SERCAs cells signaling activation histamine cancers tumorigenesis inflammation reticula sarcoplasmic endoplasmic
  • Product Overview:
    In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM).{19971,19972} Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells.{19971,19965,19970} In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects.{19977,19975}

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