24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ?-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg, 50 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 131339-24-7 |
| Molecular formula | C20H30O3 |
| Smiles | CC/C=CC[C@@H]1[C@@H](O1)C/C=CC/C=CC/C=CCCCC(O)=O, CC/C=CC[C@@H]1[C@@H](O1)C/C=CC/C=CC/C=CCCCC(O)=O, CC/C=CC[C@@H]1[C@@H](O1)C/C=CC/C=CC/C=CCCCC(O)=O, CC/C=CC[C@@H]1[C@@H](O1)C/C=CC/C=CC/C=CCCCC(O)=O |
| Molecular weight | 318,5 |
| Custom code | 2910.90 |
| Formulation | A solution in ethanol |
| Purity | ≥90% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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