Ursolic Acid

Ursolic Acid

CAT N°: 10072
Price:

From 49.00 41.65

Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila and has diverse biological activities, including anticancer, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, and cardioprotective properties.{45002,15043,45003,45004} It inhibits the proliferation of HepG2 liver, MCF-7 breast, and Caco-2 colon cancer cells (EC50s = 87.4, 14.4, and 34.4 ?M, respectively).{15043} Ursolic acid reverses increases in hepatic steatosis, levels of hepatic triglycerides and free fatty acids, and hepatic TNF-?, IL-1?, IL-6, and IL-8 mRNA expression in a dose-dependent manner in a high-fat diet-induced rat model of non-alcoholic fatty liver disease (NAFLD).{45004} Ursolic acid also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 59.7 ?g/ml) and inhibits the growth of several strains of Gram-positive and Gram-negative bacteria in vitro including S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and S. flexneri (MICs = 32-512 ?g/ml).{45003}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3?-hydroxy-urs-12-en-28-oic acid
  • Correlated keywords
    • NSC-167406 NSC167406 NSC-4060 NSC4060 neoage UR ursolisome urson ?-209545-05-1 anti-oxidant microbial antioxidative antiinflammatory Na+ K+ ATPase NF-kB apoptosis inflammation Staphylococcus Escherichia Pseudomonas Klebsiella Shigella Hep-G2 HepG-2 TNF? IL1? IL6 IL8 MCF7 Caco2
  • Product Overview:
    Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila and has diverse biological activities, including anticancer, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, and cardioprotective properties.{45002,15043,45003,45004} It inhibits the proliferation of HepG2 liver, MCF-7 breast, and Caco-2 colon cancer cells (EC50s = 87.4, 14.4, and 34.4 ?M, respectively).{15043} Ursolic acid reverses increases in hepatic steatosis, levels of hepatic triglycerides and free fatty acids, and hepatic TNF-?, IL-1?, IL-6, and IL-8 mRNA expression in a dose-dependent manner in a high-fat diet-induced rat model of non-alcoholic fatty liver disease (NAFLD).{45004} Ursolic acid also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 59.7 ?g/ml) and inhibits the growth of several strains of Gram-positive and Gram-negative bacteria in vitro including S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and S. flexneri (MICs = 32-512 ?g/ml).{45003}

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