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- Product Overview:
The vitamin A metabolite retinoic acid (RA) regulates gene transcription by activating several members of the nuclear receptor family of ligand-activated transcription factors: the classical RA receptors RARα, RARβ, and RARγ and the peroxisome proliferator-activated receptor β/δ (PPARβ/δ). The partitioning of the hormone between its receptors is regulated by two intracellular lipid-binding proteins, cellular retinoic acid-binding protein type II (CRABP-II), which delivers RA to RAR, and fatty acid-binding protein type 5 (FABP5), which shuttles it to PPARβ/δ.