€199.00 €169.15
To be used in conjunction with Cayman’s LPA1 polyclonal antibody (Catalog No. 10005280) to block protein-antibody complex formation during immunochemical analysis of LPA1. · LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).{13001} LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).{11049} LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element, and cell proliferation.{11808,12477} LPA1 mRNA is detected in a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.{11810,12912} Murine and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.{12477} Cayman’s LPA1 polyclonal antibody detects the protein from several species at 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 ea |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 200 µg of blocking peptide lyophilized from TBS, pH 7.4 |
| Custom code | 3504.00 |
| UNSPSC code | 41105329 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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