β-Boswellic Acid

CAT N°: 11693

Price:

From ~~€66.00~~ €56.10

β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}

Product overview

Data

Downloads

About Cayman

Product overview

Territorial Availability: Available through Bertin Technologies only in France

Synonyms
- (3?,4?)-3-hydroxy-urs-12-en-23-oic acid
Correlated keywords
- 1285527-37-8 5LO HL60NO NO
Product Overview:
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}

Data

Size	1 mg, 10 mg, 5 mg
Shipping	dry ice
CAS Number	631-69-6
Molecular Formula	C30H48O3
SMILES	O[C@@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]1(C(O)=O)C
Molecular Weight	456,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2918.99
UNSPSC code	12352100