€474.00 €402.90
Secretory phospholipase A2 (sPLA2) (Type V) is a calcium-dependent phospholipase A2 superfamily member that is encoded by PLA2G5 in humans.{56210} It is composed of a highly conserved calcium-binding loop, a heparin-binding domain, and a C-terminal domain that contains a catalytic histidine-aspartic acid dyad and cationic residues that are essential for cell membrane association. Pla2g5 is constitutively expressed in the heart, lung, and spleen and is induced by proinflammatory stimuli in a variety of immune cells and tissues.{12947} Upon activation, sPLA2 (Type V) is released into the extracellular space where it acts in a paracrine or autocrine manner to catalyze the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating the free fatty acid and lysophospholipid, which serve as substrates for the synthesis of bioactive lipid metabolites.{56210} Pla2g5-/- mice have decreased airway and bronchoalveolar lavage fluid (BALF) neutrophil infiltration in a model of acute lung injury induced by LPS.{56211} Neonatal mice overexpressing Pla2g5 have increased BALF prostaglandin E2 (PGE2; Item No. 14010) levels, as well as reduced lung surfactant levels, leading to respiratory failure and death by postnatal day one.{56212} SNPs in PLA2G5 are associated with increased plasma LDL and total cholesterol levels in individuals with type 2 diabetes.{56213} Cayman’s sPLA2 (mouse Type V) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes sPLA2 (Type V) at 16 kDa from human, mouse, and rat samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Synthetic peptide from an internal region of mouse protein |
| Application(s) | WB |
| Formulation | 500 µl of peptide affinity-purified antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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