Eeyarestatin 1

Eeyarestatin 1

CAT N°: 10012609
Price:

From 83.00 70.55

Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
  • Correlated keywords
    • biochemical inhibitor ubiquitin proteasome ERAD terminally misfolded protein chaperones endoplasmic reticulum ER depot ubiquitinylation proteasomal degradation ER-associated pathway Eeyarestatin1 inhibit blocking block p97-associted deubiquitinylating complex cells preventing prevent deubiquitinylation substrate ataxin-3 ataxin3 retrograde anterograde trafficking toxin viruses virus
  • Product Overview:
    Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}

We also advise you