PD 184161

PD 184161

CAT N°: 10012431
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From 42.00 35.70

The mitogen-activated protein (MAP) kinase intracellular signaling pathways are involved in the regulation of various cellular functions.{17156} One of these pathways, the Raf/MEK/ERK pathway, plays a major role in the regulation of cellular growth, differentiation, and proliferation. The modulation of this cascade has been studied as a useful approach to treating proliferative disorders such as cancer.{15421,15629} PD 184161 is a potent and selective inhibitor of MEK1/2 with an IC50 value that ranges from 10-100 nM. {15628} More effective at inhibiting phosphorylation of ERK1/2 than the selective MEK inhibitors, PD 098059 and U0126, PD 184161 is useful both in vitro and in vivo for studying the pharmacological role of the Raf/MEK/ERK pathway.{15628} PD 184161 is structurally related to clinically-studied MEK inhibitors PD184352 (CI-1040) and PD 325901 and has been shown to inhibit cell proliferation, induce apoptosis, and possess antitumor activity in MEK-dependent cancers.{15628}

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