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CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling.{15705,15706} CaMKII is expressed in many different tissues but is specifically found in neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed ? genes) and 60 kDa (? genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site.{15707,15708,15709,15710,15711} The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase.{15712} This kinase activation results in autophosphorylation at threonine 286 (Thr286).{15712} The threonine phosphorylation state of CaMKII can be regulated through protein phosphatase 1 (PP1)/protein kinase A (PKA). Whereas PP1 dephosphorylates phospho-CaMKII at Thr286, PKA prevents this dephosphorylation.{15713} Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.{15714,15715,15716}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Antigen | rat recombinant CaMKII |
| Host | Mouse |
| Clone | clone 6G9 |
| Isotype | IgG1 |
| Custom code | 3822.19 |
| Application(s) | ELISA, IF, IP, WB, IHC |
| Formulation | Protein G-purified mouse IgG at a concentration of 1 mg/ml in PBS, pH. 7.4, containing 50% glycerol and 0.09% sodium azide |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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