GW 5074

GW 5074

CAT N°: 10010368
Price:

From 55.00 46.75

Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.{14539,15155} This pathway mediates basic cellular functions, including proliferation, differentiation, and survival.{14539} GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM).{24584} It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.{24584} GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.{24584}

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