BMS309403

BMS309403

CAT N°: 10010206
Price:

66.00 56.10

Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP.{25740} BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki is = 250 and 350 nM, respectively).{25745} BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E.{14840,25741} It also protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.{14840,25744} FABP4 dose-dependently suppresses the release of MCP-1 from macrophages.{25740,25744}

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