Entecavir-d<sub>2</sub>

Entecavir-d2

CAT N°: 37212
Price:

655.00 556.75

Entecavir-d2 is intended for use as an internal standard for the quantification of entecavir (Item Nos. 36926 | 13831) by GC- or LC-MS. Entecavir is an antiviral nucleoside analog of 2′-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM).{22164,59703} It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate.{59703,53861} Entecavir reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with hepatitis B virus (HBV; EC50 = 3.75 nM).{22164} It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg.{22166} Formulations containing entecavir have been used in the treatment of chronic HBV infection.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
  • Correlated keywords
    • Baraclude BMS 200475 BMS200475 ETV SQ 34676 SQ34676 GCMS LCMS deuterated deuterium anti viral deoxy guanosine HepG 2
  • Product Overview:
    Entecavir-d2 is intended for use as an internal standard for the quantification of entecavir (Item Nos. 36926 | 13831) by GC- or LC-MS. Entecavir is an antiviral nucleoside analog of 2′-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM).{22164,59703} It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate.{59703,53861} Entecavir reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with hepatitis B virus (HBV; EC50 = 3.75 nM).{22164} It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg.{22166} Formulations containing entecavir have been used in the treatment of chronic HBV infection.

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