(R,S)-Anatabine-d<sub>4</sub>

(R,S)-Anatabine-d4

CAT N°: 37198
Price:

907.00 770.95

(R,S)-Anatabine-d4 is intended for use as an internal standard for the quantification of (R,S)-anatabine (Item Nos. 11001 | 15132) by GC- or LC-MS. (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).{20193} It is an agonist of ?4?2 and ?6/?3?2?4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC50s = 6.1 and 3.6 µM, respectively). It is selective for ?4?2 and ?6/?3?2?4 subunit-containing nAChRs over ?3?4 subunit-containing nAChRs or ?7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively).{69082} (R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund’s adjuvant (CFA), and M. tuberculosis.{69083} It decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively).{69084} (R,S)-Anatabine has been used as a biomarker of tobacco use.{20195,20196}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,2,3,6-tetrahydro-2,3?-bipyridine-2?,4?,5?,6?-d4
  • Correlated keywords
    • deuterated deuterium GCMS LCMS ?4-?2 ?3-?2-?4 nAChR Mycobacterium
  • Product Overview:
    (R,S)-Anatabine-d4 is intended for use as an internal standard for the quantification of (R,S)-anatabine (Item Nos. 11001 | 15132) by GC- or LC-MS. (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).{20193} It is an agonist of ?4?2 and ?6/?3?2?4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC50s = 6.1 and 3.6 µM, respectively). It is selective for ?4?2 and ?6/?3?2?4 subunit-containing nAChRs over ?3?4 subunit-containing nAChRs or ?7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively).{69082} (R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund’s adjuvant (CFA), and M. tuberculosis.{69083} It decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively).{69084} (R,S)-Anatabine has been used as a biomarker of tobacco use.{20195,20196}

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