PtdIns-<wbr/>(3,4,5)-<wbr/>P<sub>3</sub> Binding Protein

PtdIns-(3,4,5)-P3 Binding Protein

CAT N°: 10009817
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From 213.00 181.05

Pleckstrin homology (PH) domains all contain a seven-standard ?-sandwich that allows binding to various species of phosphatidyl inositol (PtdIns) phosphates.{15263} Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3 (see Figure 1).{15107} PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096, 8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signalling cascade that has been implicated in cancer.{12235} Due to PtdIns-(3,4,5)-P3 binding protein · s unique affinity for PtdIns-(3,4,5)-P3, this protein can be used to detect product formed by PI3-kinase in in vitro assays. Cayman’s PtdIns-(3,4,5)-P3 Binding Protein is isoform 2, which differs from isoform 1 by the absence of a glycine residue at position 277.

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