W140 (trifluoro<wbr/>acetate salt)

W140 (trifluoroacetate salt)

CAT N°: 10009110
Price:

From 117.00 99.45

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material).{14254} It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • [3S-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)
  • Correlated keywords
    • S1P sphingosine-1-phosphate sphingosines phosphates lymphocytes S1P1 antagonists immunity TFA
  • Product Overview:
    Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material).{14254} It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

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