€805.00 €684.25
DNA methyltransferase 3B (DNMT3B) and DNMT3L are members of the DNMT3 family.{19542,66086} DNMT3B is composed of variable N-terminal, proline-tryptophan-tryptophan-proline (PWWP), cysteine-rich, and C-terminal catalytic domains. DNMT3L has a similar sequence to DNMT3B but lacks the PWWP domain and residues in the C-terminal domain that are required for DNA methyltransferase activity.{19542} DNMT3B and DNMT3A are responsible for de novo methylation of cytosines in cytosine-phosphate-guanine (CpG) sites of DNA in germ cells and embryos and DNMT3L is required for their activity.{19542,66086,19545} The methylation patterns established by the DNMT3 family are maintained by DNMT1.{66086} Mutations in DNMT3B are associated with ICF syndrome, which is characterized by immune defects, centromeric instability, and facial anomalies.{19542} Cayman’s DNMT3B/DNMT3L Complex (human, recombinant) protein can be used for enzyme assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 16 mM glutathione, and 20% glycerol |
| Purity | ≥90% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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