Zafirlukast

Zafirlukast

CAT N°: 10008282
Price:

28.00 23.80

Zafirlukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 0.014 ?M in a cell-based calcium mobilization assay).{49502} It is selective for CysLT1 over CysLT2 receptors (IC50 = 58 ?M). It inhibits mucus secretion induced by leukotriene D4 (LTD4; Item No. 20310) in isolated guinea pig trachea (IC50 = 0.6 ?M).{46532} Zafirlukast (5 ?M) inhibits ovalbumin-induced increases in tracheal mucus secretion in ovalbumin-sensitized guinea pigs by 65%. It inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 61 nmol/kg, i.v.).{10911} Formulations containing zafirlukast have been used in the prophylaxis and chronic treatment of asthma.

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