€615.00 €522.75
ERK1 and ERK2, also known as ERK1/2, are serine/threonine protein kinases and essential components of the MAP kinase signaling cascade.{55459} They share 84% sequence homology and are each composed of a glycine-rich loop, hinge region, and protein kinase domain containing a catalytic HRD motif, activation segment, and kinase insert domain. ERK1/2 are ubiquitously expressed though ERK2 is expressed at higher levels than ERK1 and is predominant in the brain and hematopoietic cells.{55463,55464} Both isoforms localize to the cytosol anchored to MEK1/2.{55459} Upon extracellular stimulation with mitogens, growth factors, or cytokines, the MAP kinase signaling cascade is initiated and terminates with dual phosphorylation of ERK1 and ERK2 in the activation segment’s activation lip at Thr202/Tyr204 or Thr185/Tyr187, respectively, by MEK1/2.{53684,53685,55459,55460} Upon activation, ERK1/2 phosphorylate and activate substrates in the cytosol or various subcellular compartments, including the nucleus where they induce activation of transcription factors involved in cell proliferation, differentiation, and the stress response.{55461,55462,53684,53685} Misregulation of the MAP kinase cascade drives development of various cancers.{53684,53685} Cayman’s ERK1/2 (Phospho-Thr202/Tyr204) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human ERK1/2 (phospho-Thr202/Tyr204) |
| Clone | RM451 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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