Pravadoline

Pravadoline

CAT N°: 10006973

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.{13045} Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 ?M in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).{13045} In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 ?M), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.{13045} Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.{13045}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Please check regulation status before ordering; additionel fees can apply.

  • Synonyms
    • (4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone
  • Correlated keywords
    • Anti-inflammatory analgesic inhibitor COX AAI NSAIDs prostaglandins PGs synthesis cyclooxygenases opioid WIN48098 WIN-48098 WIN-48,8098 analytical references standards
  • Product Overview:
    Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.{13045} Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 ?M in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).{13045} In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 ?M), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.{13045} Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.{13045}

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