Vasoactive Eicosanoid HPLC Mixture
Vasoactive Eicosanoid HPLC Mixture
This mixture contains the characteristic metabolites of both PGI2 and TXA2. Contents: Thromboxane B2, 11-dehydro Thromboxane B2, 6-keto Prostaglandin F1?,...
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Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.{1286} Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered.{722} Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.{4068}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 10 g, 5 g, 50 g |
|---|---|
| Shipping | dry ice |
| CAS number | 38194-50-2 |
| Molecular formula | C20H17FO3S |
| Smiles | FC1=CC=C(/C(C(C)=C2CC(O)=O)=CC3=CC=C(S(C)=O)C=C3)C2=C1, FC1=CC=C(/C(C(C)=C2CC(O)=O)=CC3=CC=C(S(C)=O)C=C3)C2=C1, FC1=CC=C(/C(C(C)=C2CC(O)=O)=CC3=CC=C(S(C)=O)C=C3)C2=C1, FC1=CC=C(/C(C(C)=C2CC(O)=O)=CC3=CC=C(S(C)=O)C=C3)C2=C1 |
| Molecular weight | 356,4 |
| Custom code | 2930.90 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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