2-<wbr/>Nonylquinolin-<wbr/>4(1H)-one-d<sub>4</sub>

2-Nonylquinolin-4(1H)-one-d4

CAT N°: 9003970
Price:

507.00 430.95

2-Nonylquinolin-4(1H)-one-d4 is intended for use as an internal standard for the quantification of 2-nonylquinolin-4(1H)-one (Item No. 9003627) by GC- or LC-MS. 2-Nonylquinolin-4(1H)-one is a quinolone alkaloid that has been found in P. aeruginosa and has diverse biological activities.{58183},{58184},{58185},{58188} It reduces infection of Huh7.5 cells by hepatitis C virus (HCV) with an IC50 value of 1.4 µg/ml.{58183} 2-Nonylquinolin-4(1H)-one (50 and 100 µg/ml) is also active against L. gongylophorus, a symbiotic fungus of the agricultural pest A. sexdens (leaf-cutting ant).{58184} It inhibits activation of nuclear factor of activated T cells (NFAT) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) in Jurkat cells (IC50 = 3.44 µM), but not LPS-induced NF-?B activation in RAW 264.7 cells (IC50 = >100 µM), in reporter assays.{58185}

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