Geranylgeranoic Acid

Geranylgeranoic Acid

CAT N°: 9003474
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Geranylgeranoic acid (GGA) is an isoprenoid that has been found in S. chinensis and has anticancer activity.{53890} It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 µM. GGA (10 µM) induces apoptosis in Huh7 cells via loss of the mitochondrial membrane potential and activation of interleukin-1?-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).{53891} It also inhibits lysine-specific demethylase 1 (LSD1; IC50 = 46.97 µM).{53892}

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