24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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9(Z),11(E),13(E)-Octadecatrienoic acid ethyl ester (?-ESA ethyl ester) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.{14176} ?-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.{14175} It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, ?-ESA induced apoptosis through up-regulation of GADD45, p53, and PPAR?.{14176} In DLD-1 cells supplemented with ?-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM.{14175} It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.{14174} ?-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 42021-86-3 |
| Molecular formula | C20H34O2 |
| Smiles | CCCC/C=C/C=C/C=CCCCCCCCC(OCC)=O, CCCC/C=C/C=C/C=CCCCCCCCC(OCC)=O, CCCC/C=C/C=C/C=CCCCCCCCC(OCC)=O |
| Molecular weight | 306,5 |
| Custom code | 2916.19 |
| Formulation | A solution in ethanol |
| Purity | ≥90% |
| UNSPSC code | 12352100 |
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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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