99,00 SHP

99,00 SHP

CAT N°: 20000
Price:

From 66.00 56.10

SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM).{34164,34163} It stabilizes SHP2 in an auto-inhibited conformation.{34163} SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo.{34163}

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