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F2 isoprostanes (F2-iPs) are thought to arise from the free radical-mediated peroxidation of phospholipid-bound arachidonic acid.{6910} They are cleaved, presumably by an unidentified phospholipase A2, and are found in the circulation and the urine. 8,12-iso-iPF2?-VI-1,5-lactone is a racemic mixture of the lactone forms of the free acid, 8,12-iso- iPF2?-VI. Previously called IPF2? -I,{320} the free acid form, iPF2?-VI, is the most abundant F2-iP regioisomer measured in the urine of rats treated with CCl4 to induce lipid peroxidation.{5603} iPF2?-VI is the only regioisomer that undergoes lactonization, and this occurs slowly in vivo or can be driven chemically.{17353} The less polar lactone is readily separated from the free acid forms of iPF2?.{17353} While the level of iPF2?-VI in plasma, urine and organs is used as a biomarker for oxidative stress,{17354,17355} some F2-iPs also evoke significant biological effects.{16559} It is not known if 8,12-iso-iPF2?-VI-1,5-lactone has important physiological effects.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg, 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C20H32O4 |
| Smiles | O[C@H]1[C@@H](C/C=CCCCCC)[C@@H](/C=C/C2OC(CCC2)=O)[C@@H](O)C1, O[C@H]1[C@@H](C/C=CCCCCC)[C@@H](/C=C/C2OC(CCC2)=O)[C@@H](O)C1, O[C@H]1[C@@H](C/C=CCCCCC)[C@@H](/C=C/C2OC(CCC2)=O)[C@@H](O)C1 |
| Molecular weight | 336,5 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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