8-<wbr/><em>iso</em> Prostaglandin F<sub>2?</sub>

8-iso Prostaglandin F2?

CAT N°: 16350
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From 109.00 92.65

8-iso PGF2? is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It is present in human plasma in two distinct forms – esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2? level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2? levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2? is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2? inhibits platelet aggregation induced by U-46619 (10?6 M) and I-BOP (3 x 10?7 M) with IC50 values of 1.6 x 10?6 M and 1.8 x 10?6 M, respectively.{855}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9?,11?,15S-trihydroxy-(8?)-prosta-5Z,13E-dien-1-oic acid
  • Correlated keywords
    • 8-isoprostanes vasoconstriction 8-epi-PGF2.alpha. 8-epi-PGF2alpha 8-iso-PGF2.alpha. 8-iso-PGF2alpha prostaglandins
  • Product Overview:
    8-iso PGF2? is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It is present in human plasma in two distinct forms – esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2? level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2? levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2? is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2? inhibits platelet aggregation induced by U-46619 (10?6 M) and I-BOP (3 x 10?7 M) with IC50 values of 1.6 x 10?6 M and 1.8 x 10?6 M, respectively.{855}

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