8-<wbr/><em>iso</em> Prostaglandin E<sub>2</sub>-<wbr/>d<sub>4</sub>

8-iso Prostaglandin E2–d4

CAT N°: 10011321
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From 245.00 208.25

8-iso Prostaglandin E2-d4 (8-iso PGE2-d4) contains four deuterium atoms at the hydroxyethyl 3, 3′,4, and 4′ positions. It is intended for use as an internal standard for the quantification of 8-iso PGE2 by GC- or LC-mass spectrometry. 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}

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