7-hydroxy Methotrexate (sodium salt)

7-hydroxy Methotrexate (sodium salt)

CAT N°: 21788
Price:

From 182.00 154.70

7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX (Item No. 13960), which is converted by hepatic aldehyde oxidases.{34769} Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models. It and the parent compound rapidly accumulate when all three transporters are absent.{34771} Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.{21829,7669} Various methods have been described to quantify 7-hydroxy MTX levels during cancer therapy to avoid toxicity.{34772,34770}

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