7-<wbr/>dehydro Cholesterol

7-dehydro Cholesterol

CAT N°: 14612
Price:

From 57.00 48.45

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol.{22849} It is reduced to cholesterol by the enzyme 3?-hydroxysterol-?7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features.{22849,27281} It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS.{22849} 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611).{22849} 7-DHC is a provitamin that is converted to vitamin D3 (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.{23284,23286}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • cholesta-5,7-dien-3?-ol
  • Correlated keywords
    • neurosciences steroids signals transductions nutrition cholesterols DHC 7DHC DHCR7 squalene smith-lemli-opitz smith lemli opitz syndromes SLOS free radical oxidation autoxidation oxysterols pathogenesis ultraviolet lights vitamins D3 NSC18159 NSCs NSC-18159 provitamins cholecalciferol diets precusors enzymes hydroxysterol biosynthesis squalene mutations genes encoding encodes SLOS rats inhibits inhibition inhibitors AY9944 animals models serum livers skin ultraviolet lights dehydrocholesterol ?5,7-cholestadien-3?-ol
  • Product Overview:
    7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol.{22849} It is reduced to cholesterol by the enzyme 3?-hydroxysterol-?7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features.{22849,27281} It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS.{22849} 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611).{22849} 7-DHC is a provitamin that is converted to vitamin D3 (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.{23284,23286}

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