666-15

666-15

CAT N°: 30780
Price:

From 231.00 196.35

666-15 is an inhibitor of gene transcription mediated by cAMP-response-element-binding protein (CREB; IC50 = 81 nM in a cell-based reporter assay).{56180} It inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 ?M, respectively). 666-15 (10 mg/kg per day, five days per week) reduces tumor growth in an MDA-MB-468 mouse xenograft model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(3-aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide, monohydrochloride
  • Correlated keywords
    • 1433286-57-7 66615 A 549 MCF7 MDAMB231 MDAMB MB231 MDAMB468 MB468
  • Product Overview:
    666-15 is an inhibitor of gene transcription mediated by cAMP-response-element-binding protein (CREB; IC50 = 81 nM in a cell-based reporter assay).{56180} It inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 ?M, respectively). 666-15 (10 mg/kg per day, five days per week) reduces tumor growth in an MDA-MB-468 mouse xenograft model.

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