6-OHDA (hydrobromide)

6-OHDA (hydrobromide)

CAT N°: 25330
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From 55.00 46.75

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 ?g, respectively.{37727} Intracisternal administration of 6-OHDA (200 ?g) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 ?M.{37723,37724} 6-OHDA (75 ?M) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}

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