6?-Naltrexol

6?-Naltrexol

CAT N°: 15896

6?-Naltrexol (Item No. 15896) is an analytical reference material that is structurally categorized as an opioid. It is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520).{32375} Unlike naltrexone, which acts as a µ-receptor antagonist or inverse agonist, 6?-naltrexol is a neutral opioid antagonist.{32377} 6?-Naltrexol binds the µ-opioid receptor more potently than naloxone (Item Nos. ISO60191 | 15594) or naltrexone (Kis = 94, 420, and 265 pM, respectively) but is ~100-fold less effective at blocking morphine-modulated pain in vivo, as assessed using the mouse hotplate test.{32376} This product is intended for research and forensic applications.

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Reference Materials RMs and Certified Reference Materials CRMs are dispatched directly to the end-user in accordance with ISO requirements. Please check regulation status before ordering; additionel fees can apply.

  • Synonyms
    • (5?,6?)-17-(cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol
  • Correlated keywords
    • hydroxynaltrexone µ-receptor u
  • Product Overview:
    6?-Naltrexol (Item No. 15896) is an analytical reference material that is structurally categorized as an opioid. It is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520).{32375} Unlike naltrexone, which acts as a µ-receptor antagonist or inverse agonist, 6?-naltrexol is a neutral opioid antagonist.{32377} 6?-Naltrexol binds the µ-opioid receptor more potently than naloxone (Item Nos. ISO60191 | 15594) or naltrexone (Kis = 94, 420, and 265 pM, respectively) but is ~100-fold less effective at blocking morphine-modulated pain in vivo, as assessed using the mouse hotplate test.{32376} This product is intended for research and forensic applications.

We also advise you