6-hydroxy Melatonin

6-hydroxy Melatonin

CAT N°: 21857
Price:

From 122.00 103.70

6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).{26017,34286,30338,60504,60505} It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{60506} 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.{26017,34286} It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 µM).{30338} 6-hydroxy Melatonin (10 and 100 µM) reduces increases in the levels of NF-?B, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.{60504} It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.{60505}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide
  • Correlated keywords
    • hydroxymelatonin MT-1 2 anti-oxidative anti-oxidant ROS 6OH-mel OHmel 6OHM Interleukin IL6 IL8 NF?B MT 1B
  • Product Overview:
    6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).{26017,34286,30338,60504,60505} It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{60506} 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.{26017,34286} It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 µM).{30338} 6-hydroxy Melatonin (10 and 100 µM) reduces increases in the levels of NF-?B, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.{60504} It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.{60505}

We also advise you