6-hydroxy Bexarotene

6-hydroxy Bexarotene

CAT N°: 22098
Price:

92.00 78.20

6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXR?, RXR?, and RXR? as well as retinoic acid receptor ? (RAR?; Kds = 3.46, 4.21, 4.83, and 8.17 ?M, respectively). It selectively activates RXR?, RXR?, and RXR? over RAR?, RAR?, and RAR? in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).

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