6-<wbr/>Formylpterin

6-Formylpterin

CAT N°: 14247
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From 122.00 103.70

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}

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